L(-)-5-Methyl-5,6,7,8-tetrahydrofolic acid
L-5-Methyltetrahydrofolate
CAS: 31690-09-2
Molecular Formula: C20H25N7O6
L(-)-5-Methyl-5,6,7,8-tetrahydrofolic acid - Names and Identifiers
L(-)-5-Methyl-5,6,7,8-tetrahydrofolic acid - Physico-chemical Properties
| Molecular Formula | C20H25N7O6 |
| Molar Mass | 459.46 |
| Density | 1.62 |
| Melting Point | 215-218oC |
| Solubility | Aqueous Base (Slightly, Heated, Sonicated), DMSO (Slightly) |
| Appearance | Solid |
| Color | Off-White to Light Green |
| pKa | 3.51±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
L(-)-5-Methyl-5,6,7,8-tetrahydrofolic acid - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.176 ml | 10.882 ml | 21.765 ml |
| 5 mM | 0.435 ml | 2.176 ml | 4.353 ml |
| 10 mM | 0.218 ml | 1.088 ml | 2.176 ml |
| 5 mM | 0.044 ml | 0.218 ml | 0.435 ml |
Last Update：2024-01-02 23:10:35
L(-)-5-Methyl-5,6,7,8-tetrahydrofolic acid - Reference Information
| Introduction | 5-methyltetrahydrofolic acid is the folic acid metabolism pathway that converts 5,10-methylenetetrahydrofolic acid into 5-methyltetrahydrofolic acid with biological functions. 5-Methyltetrahydrofolate can further enter the methyl transmission pathway, indirectly providing methyl for DNA methylation and protein methylation through the remethylation process of homocysteine and keeping the homocysteine level in the blood at a low level. |
| Application | 5-methyltetrahydrofolic acid is the most biologically active and functional form of folic acid. It is the only way for folic acid to participate in physiological metabolism, and it is also present in animal plasma and The only form of free folic acid in cells. Mainly used for pharmaceutical active ingredients and food additives, to prevent fetal neural tube defects, arteriosclerosis, treat megaloblastic anemia, enhance the therapeutic effect of fluorinated pyrimidine, and treat autoimmune diseases such as psoriasis and rheumatoid arthritis. |
| Effect | Ordinary folic acid supplements, namely inactive folic acid, need to be transformed into an active form of folic acid structure (5-methyltetrahydrofolic acid) in the body through genes and related metabolism. The biological effect, the efficiency of converting into 5-methyltetrahydrofolic acid that can be absorbed by the human body is extremely low, it is also easy to cause the loss of folic acid during the processing of raw materials. Widely existing studies in China have shown that the proportion of MTHFR (the key gene for transforming active folic acid in the body) gene mutation defects in China is higher than that in European and American countries, resulting in the inability of active folic acid metabolism to effectively transform and play a role, resulting in cell dysfunction. 5 Methyltetrahydrofolate can pass through the blood-brain barrier and be effectively absorbed and utilized by the brain. It is the active folate form of nutrition that the human body preferentially absorbs and utilizes. Patients with MTHFR gene mutation need to pay more attention to daily supplementation of active folic acid for effective absorption and utilization. |
| biological activity | Levomefolic acid (5-MTHF) is a natural active form of folic acid. |
Last Update：2024-04-09 21:11:58
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